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1

In-Depth Study of Tripeptide-Based α-Ketoheterocycles as Inhibitors of Thrombin. Effective Utilization of the S1‘ Subsite and Its Implications to Structure-Based Drug Design1

Costanzo, Michael J., Almond, Harold R., Hecker, Leonard R., Schott, Mary R., Yabut, Stephen C., Zhang, Han-Cheng, Andrade-Gordon, Patricia, Corcoran, Thomas W., Giardino, Edward C., Kauffman, Jack A.

Journal:

Journal of Medicinal Chemistry

Année:

2005

Langue:

english

Fichier:

PDF, 845 KB

english, 2005

2

Molecular diversity comes of age !

H. Mario Geysen, Richard A. Houghten, Stuart Kauffman, Michal Lebl, Walter H. Moos, Michael R. Pavia, Jack W. Szostak

Journal:

Molecular Diversity

Année:

1995

Langue:

english

Fichier:

PDF, 368 KB

english, 1995

3

Nonpeptide Inhibitors of Cathepsin G: Optimization of a Novel β-Ketophosphonic Acid Lead by Structure-Based Drug Design

Greco, Michael N., Hawkins, Michael J., Powell, Eugene T., Almond,, Harold R., Corcoran, Thomas W., de Garavilla, Lawrence, Kauffman, Jack A., Recacha, Rosario, Chattopadhyay, Debashish, Andrade-Gordo

Journal:

Journal of the American Chemical Society

Année:

2002

Langue:

english

Fichier:

PDF, 105 KB

english, 2002

4

Potent, Small-Molecule Inhibitors of Human Mast Cell Tryptase. Antiasthmatic Action of a Dipeptide-Based Transition-State Analogue Containing a Benzothiazole Ketone

Costanzo, Michael J., Yabut, Stephen C., Almond,, Harold R., Andrade-Gordon, Patricia, Corcoran, Thomas W., de Garavilla, Lawrence, Kauffman, Jack A., Abraham, William M., Recacha, Rosario, Chattopadh

Journal:

Journal of Medicinal Chemistry

Année:

2003

Langue:

english

Fichier:

PDF, 347 KB

english, 2003

5

In-Depth Study of Tripeptide-Based α-Ketoheterocycles as Inhibitors of Thrombin. Effective Utilization of the S 1 ‘ Subsite and Its Implications to Structure-Based Drug Design.

Costanzo, Michael J., Almond, Harold R., Hecker, Leonard R., Schott, Mary R., Yabut, Stephen C., Zhang, Han-Cheng, Andrade-Gordon, Patricia, Corcoran, Thomas W., Giardino, Edward C., Kauffman, Jack A.

Journal:

Journal of Medicinal Chemistry

Année:

2007

Langue:

english

Fichier:

PDF, 6 KB

english, 2007

6

Discovery of Orally Efficacious Tetrahydrobenzimidazoles as TGR5 Agonists for Type 2 Diabetes

Zhang, Xuqing, Wall, Mark, Sui, Zhihua, Kauffman, Jack, Hou, Cuifen, Chen, Cailin, Du, Fuyong, Kirchner, Thomas, Liang, Yin, Johnson, Dana L., Murray, William V., Demarest, Keith

Journal:

ACS Medicinal Chemistry Letters

Année:

2017

Langue:

english

Fichier:

PDF, 480 KB

english, 2017

7

ChemInform Abstract: Synthesis and Class III Type Antiarrhythmic Activity of 4-Aroyl (and Aryl)-1-aralkylpiperazines.

Ramesh M. Kanojia, Joseph J. Salata, Jack Kauffman

Journal:

Année:

2001

Fichier:

PDF, 27 KB

2001

8

ChemInform Abstract: 1,2,4-Triazolo[3,4-a]pyridine as a Novel, Constrained Template for Fibrinogen Receptor (GPIIb/IIIa) Antagonists.

Edward C. Lawson, William J. Hoekstra, Michael F. Addo, Patricia Andrade-Gordon, Bruce P. Damiano, Jack A. Kauffman, John A. Mitchell, Bruce E. Maryanoff

Journal:

Année:

2002

Fichier:

PDF, 32 KB

2002

9

Cyclotheonamide derivatives: Synthesis and thrombin inhibition. Exploration of specific structure-function issues

Bruce E Maryanoff, Han-Cheng Zhang, Michael N Greco, Karen A Glover, Jack A Kauffman, Patricia Andrade-Gordon

Journal:

Bioorganic & Medicinal Chemistry

Année:

1995

Langue:

english

Fichier:

PDF, 1.22 MB

english, 1995

10

Synthesis and class III type antiarrhythmic activity of 4-aroyl (and aryl)-1-aralkylpiperazines

Ramesh M. Kanojia, Joseph J. Salata, Jack Kauffman

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2000

Langue:

english

Fichier:

PDF, 225 KB

english, 2000

11

1,2,4-Triazolo[3,4-a]pyridine as a novel, constrained template for fibrinogen receptor (GPIIb/IIIa) antagonists

Edward C Lawson, William J Hoekstra, Michael F Addo, Patricia Andrade-Gordon, Bruce P Damiano, Jack A Kauffman, John A Mitchell, Bruce E Maryanoff

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2001

Langue:

english

Fichier:

PDF, 125 KB

english, 2001

12

Novel thrombin inhibitors that are based on a macrocyclic tripeptide motif

Michael N. Greco, Eugene T. Powell, Leonard R. Hecker, Patricia Andrade-Gordon, Jack A. Kauffman, Joan M. Lewis, Venkatapathy Ganesh, Alexander Tulinsky, Bruce E. Maryanoff

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

1996

Langue:

english

Fichier:

PDF, 280 KB

english, 1996

13

Thrombin receptor (PAR-1) antagonists. Heterocycle-based peptidomimetics of the SFLLR agonist motif

William J. Hoekstra, Becky L. Hulshizer, David F. McComsey, Patricia Andrade-Gordon, Jack A. Kauffman, Michael F. Addo, Donna Oksenberg, Robert M. Scarborough, Bruce E. Maryanoff

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

1998

Langue:

english

Fichier:

PDF, 456 KB

english, 1998

14

Cumulative effects of wild ungulate and livestock herbivory on riparian willows

Jack E. Brookshire, Boone J. Kauffman, Danna Lytjen, Nick Otting

Journal:

Année:

2002

Langue:

english

Fichier:

PDF, 71 KB

english, 2002

15

Plant biomass and species composition along an environmental gradient in montane riparian meadows

Kathleen A. Dwire, J. Boone Kauffman, E. N. Jack Brookshire, John E. Baham

Journal:

Année:

2004

Langue:

english

Fichier:

PDF, 256 KB

english, 2004

16

Solid-phase parallel synthesis applied to lead optimization: Discovery of potent analogues of the GPIIb/IIIa antagonist RWJ-50042

William J. Hoekstra, Bruce E. Maryanoff, Patricia Andrade-Gordon, Judith H. Cohen, Michael J. Costanzo, Bruce P. Damiano, Barbara J. Haertlein, Bruce D. Harris, Jack A. Kauffman, Patricia M. Keane, Da

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

1996

Langue:

english

Fichier:

PDF, 343 KB

english, 1996

17

COL4A2 Mutations Impair COL4A1 and COL4A2 Secretion and Cause Hemorrhagic Stroke

Marion Jeanne, Cassandre Labelle-Dumais, Jeff Jorgensen, W. Berkeley Kauffman, Grazia M. Mancini, Jack Favor, Valerie Valant, Steven M. Greenberg, Jonathan Rosand, Douglas B. Gould

Journal:

The American Journal of Human Genetics

Année:

2012

Langue:

english

Fichier:

PDF, 929 KB

english, 2012

18

Emerging paradigms in applied bioinformatics

Sergey E. Ilyin, Albert Pinhasov, Anil H. Vaidya, Frank A. Amato, Jack Kauffman, Hong Xin, Patricia Andrade-Gordon, Carlos R. Plata-Salamán, Douglas E. Brenneman

Journal:

Année:

2003

Langue:

english

Fichier:

PDF, 130 KB

english, 2003

19

Essentials of Clinical Mycology Volume 14 || Chromoblastomycosis

Kauffman, Carol A., Pappas, Peter G., Sobel, Jack D., Dismukes, William E.

Année:

2011

Langue:

english

Fichier:

PDF, 1.91 MB

english, 2011

20

Antiplatelet and Antithrombotic Activity of RWJ-53308, A Novel Orally Active Glycoprotein IIb/IIIa Antagonist

Bruce P Damiano, John A Mitchell, Edward Giardino, Thomas Corcoran, Barbara J Haertlein, Lawrence de Garavilla, Jack A Kauffman, William J Hoekstra, Bruce E Maryanoff, Patricia Andrade-Gordon

Journal:

Thrombosis Research

Année:

2001

Langue:

english

Fichier:

PDF, 616 KB

english, 2001

21

Antithrombotic Properties of RWJ-50353, a Potent and Novel Thrombin Inhibitor*

Edward C. Giardino, Michael J. Costanzo, Jack A. Kauffman, Quan Sheng Li, Bruce E. Maryanoff, Patricia Andrade-Gordon

Journal:

Thrombosis Research

Année:

2000

Langue:

english

Fichier:

PDF, 203 KB

english, 2000

22

Potent Thrombin Inhibitors That Probe the S 1 ‘ Subsite: Tripeptide Transition State Analogues Based on a Heterocycle-Activated Carbonyl Group 1

Costanzo, Michael J., Maryanoff, Bruce E., Hecker, Leonard R., Schott, Mary R., Yabut, Stephen C., Zhang, Han-Cheng, Andrade-Gordon, Patricia, Kauffman, Jack A., Lewis, Joan M., Krishnan, Raman, Tulin

Journal:

Journal of Medicinal Chemistry

Année:

1996

Langue:

english

Fichier:

PDF, 292 KB

english, 1996

23

Macrocyclic Peptide Inhibitors of Serine Proteases. Convergent Total Synthesis of Cyclotheonamides A and B via a Late-Stage Primary Amine Intermediate. Study of Thrombin Inhibition under Diverse Conditions

Maryanoff, Bruce E., Greco, Michael N., Zhang, Han-Cheng, Andrade-Gordon, Patricia, Kauffman, Jack A., Nicolaou, K. C., Liu, Aijun, Brungs, Peter H.

Journal:

Journal of the American Chemical Society

Année:

1995

Langue:

english

Fichier:

PDF, 2.71 MB

english, 1995

24

Essentials of Clinical Mycology || || Front_matter

Kauffman, Carol A., Pappas, Peter G., Sobel, Jack D., Dismukes, William E.

Année:

2011

Langue:

english

Fichier:

PDF, 1.46 MB

english, 2011

25

Essentials of Clinical Mycology || Candidiasis

Kauffman, Carol A., Pappas, Peter G., Sobel, Jack D., Dismukes, William E.

Année:

2011

Langue:

english

Fichier:

PDF, 2.85 MB

english, 2011

26

Essentials of Clinical Mycology || Paracoccidioidomycosis

Kauffman, Carol A., Pappas, Peter G., Sobel, Jack D., Dismukes, William E.

Année:

2011

Langue:

english

Fichier:

PDF, 2.21 MB

english, 2011

27

Macrocyclic Peptide Inhibitors of Serine Proteases. Convergent Total Synthesis of Cyclotheonamides A and B via a Late-Stage Primary Amine Intermediate. Study of Thrombin Inhibition under Diverse Conditions. [Erratum to document cited in CA122:161323]

Maryanoff, Bruce E., Greco, Michael N., Zhang, Han-Cheng, Andrade-Gordon, Patricia, Kauffman, Jack A., Nicolaou, K. C., Liu, Aijun, Brungs, Peter H.

Journal:

Journal of the American Chemical Society

Année:

1995

Langue:

english

Fichier:

PDF, 58 KB

english, 1995

28

Essentials of Clinical Mycology || Cryptococcosis

Kauffman, Carol A., Pappas, Peter G., Sobel, Jack D., Dismukes, William E.

Année:

2011

Langue:

english

Fichier:

PDF, 2.32 MB

english, 2011

29

Essentials of Clinical Mycology ||

Kauffman, Carol A., Pappas, Peter G., Sobel, Jack D., Dismukes, William E.

Année:

2011

Langue:

english

Fichier:

PDF, 1.46 MB

english, 2011

30

Synthesis and structure-activity relationship of 6-substituted purine derivatives as novel selective positive inotropes

Press, Jeffery B., Falotico, Robert, Hajos, Zoltan G., Sawyers, Rebecca Anne, Kanojia, Ramesh M., Williams, Louella, Haertlein, Barbara, Kauffman, Jack A., Lakas-Weiss, Constance, Salata, Joseph J.

Journal:

Journal of Medicinal Chemistry

Année:

1992

Langue:

english

Fichier:

PDF, 898 KB

english, 1992

31

LIVESTOCK EXCLUSION AND BELOWGROUND ECOSYSTEM RESPONSES IN RIPARIAN MEADOWS OF EASTERN OREGON

Kauffman, J. Boone, Thorpe, Andrea S., Brookshire, E. N. Jack

Journal:

Ecological Applications

Année:

2004

Langue:

english

Fichier:

PDF, 114 KB

english, 2004

32

Essentials of Clinical Mycology || Penicilliosis

Kauffman, Carol A., Pappas, Peter G., Sobel, Jack D., Dismukes, William E.

Année:

2011

Langue:

english

Fichier:

PDF, 2.18 MB

english, 2011

33

Molecular Basis for the Inhibition of Human α-Thrombin by the Macrocyclic Peptide Cyclotheonamide A

Bruce E. Maryanoff, Xiayang Qiu, K. P. Padmanabhan, Alexander Tulinsky, Harold R. Almond, Jr., Patricia Andrade-Gordon, Michael N. Greco, Jack A. Kauffman, K. C. Nicolaou, Aijn Liu, Peter H. Brungs an

Journal:

Proceedings of the National Academy of Sciences

Année:

1993

Langue:

english

Fichier:

PDF, 1.00 MB

english, 1993

34

Reply to Kontoyiannis

Pappas, Peter G., Kauffman, Carol A., Calandra, Thierry F., Kullberg, Bart‐Jan, Sobel, Jack D.

Journal:

Clinical Infectious Diseases

Année:

2009

Langue:

english

Fichier:

PDF, 181 KB

english, 2009

35

Essentials of Clinical Mycology || Antifungal Pharmacokinetics and Pharmacodynamics

Kauffman, Carol A., Pappas, Peter G., Sobel, Jack D., Dismukes, William E.

Année:

2011

Langue:

english

Fichier:

PDF, 1.58 MB

english, 2011

36

Essentials of Clinical Mycology || Mucormycosis and Entomophthoramycosis (Zygomycosis)

Kauffman, Carol A., Pappas, Peter G., Sobel, Jack D., Dismukes, William E.

Année:

2011

Langue:

english

Fichier:

PDF, 1.97 MB

english, 2011

37

Livestock Exclusion and Belowground Ecosystem Responses in Riparian Meadows of Eastern Oregon

J. Boone Kauffman, Andrea S. Thorpe and E. N. Jack Brookshire

Journal:

Ecological Applications

Année:

2004

Langue:

english

Fichier:

PDF, 1.80 MB

english, 2004

38

Cumulative Effects of Wild Ungulate and Livestock Herbivory on Riparian Willows

E. N. Jack Brookshire, J. Boone Kauffman, Danna Lytjen and Nick Otting

Journal:

Année:

2002

Langue:

english

Fichier:

PDF, 1.10 MB

english, 2002

39

Plant Biomass and Species Composition along an Environmental Gradient in Montane Riparian Meadows

Kathleen A. Dwire, J. Boone Kauffman, E. N. Jack Brookshire and John E. Baham

Journal:

Année:

2004

Langue:

english

Fichier:

PDF, 2.15 MB

english, 2004

40

Targeting the Nuclear Export Protein XPO1/CRM1 Reverses Epithelial to Mesenchymal Transition

Azmi, Asfar S., Muqbil, Irfana, Wu, Jack, Aboukameel, Amro, Senapedis, William, Baloglu, Erkan, Bollig-Fischer, Aliccia, Dyson, Gregory, Kauffman, Michael, Landesman, Yosef, Shacham, Sharon, Philip, P

Journal:

Scientific Reports

Année:

2015

Langue:

english

Fichier:

PDF, 1.74 MB

english, 2015

41

Evaluation of anti-diabetic effect and gall bladder function with 2-thio-5-thiomethyl substituted imidazoles as TGR5 receptor agonists

Zhang, Xuqing, Sui, Zhihua, Kauffman, Jack, Hou, Cuifen, Chen, Cailin, Du, Fuyong, Kirchner, Thomas, Liang, Yin, Johnson, Dana, Murray, William V., Demarest, Keith

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2017

Langue:

english

Fichier:

PDF, 1.53 MB

english, 2017

42

6-Benzhydryl-4-amino-quinolin-2-ones as Potent Cannabinoid Type 1 (CB1) Receptor Inverse Agonists and Chemical Modifications for Peripheral Selectivity

Zhang, Yuemei, Greco, Michael, Macielag, Mark J, Teleha, Christopher A, DesJarlais, Renee, Tang, YuTing, Ho, George, Hou, Cuifen, Chen, Cailin, Zhao, Shuyuan, Kauffman, Jack, Camacho, Raul, Qi, Jenson

Journal:

Journal of Medicinal Chemistry

Année:

2018

Langue:

english

Fichier:

PDF, 875 KB

english, 2018

43

Structure-Function Study of Quinazolinone-Based Vitronectin Receptor (αVβ3) Antagonists: Computer-Assisted Analysis of Ligand-Receptor Interactions

Lawson, Edward, Kinney, William, Costanzo, Michael, Hoekstra, William, Kauffman, Jack, Luci, Diane, Santulli, Rosemary, Tounge, Brett, Yabut, Stephen, Andrade-Gordon, Patricia

Journal:

Letters in Drug Design & Discovery

Année:

2004

Langue:

english

Fichier:

PDF, 137 KB

english, 2004

44

Discovery of PEGylated 6-Benzhydryl-4-amino-quinazolines as Peripherally Restricted CB 1 R Inverse Agonists

Zhang, Yue-Mei, Greco, Michael, Le Blanc, Tonya, Lang, Wensheng, Kauffman, Jack, Masucci, John, Murray, William V., Demarest, Keith, Macielag, Mark Joseph

Journal:

ACS Medicinal Chemistry Letters

Année:

2020

Fichier:

PDF, 1.65 MB

2020